AB de Villiers and Chris Morris will return to the team after missing the Australia series last year, while youngster Lungi Ngidi has received his first ODI call-up.
Convener of selectors Linda Zondi says they have cover for the inexperienced players, should they fail to deliver.
Zondi says they've introduced young players because they're starting to build for the 2019 World Cup.
“We're not building for the championship, we are building for 2019 World Cup. The focus for me is the 2019 World Cup and the championship is part of that. I am quite comfortable with where we're at.”
He adds says they're happy with the experience they have in the batting order and want the young guys to gain their experience now.